Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal
tissue development, homeostasis, and repair of damaged tissue. Macrophage function is …

The influenza viruses are some of the most important human pathogens, causing substantial
seasonal and pandemic morbidity and mortality. In humans, infection of the lower …

Mammalian cells have divergent responses to varying oxygen levels. Cells exposed to low
oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as …

Background Experimental studies in animals and observational studies in humans suggest
that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most …

Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in
mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic glycolysis …

Mammalian cells increase transcription of genes for adaptation to hypoxia through the
stabilization of hypoxia-inducible factor 1α (HIF-1α) protein. How cells transduce hypoxic signals …

Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome 1 (ARDS). Distinct …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …

The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial
role in lung pathology. The accurate identification and enumeration of these subsets are …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…