Setup and validation of shake-flask procedures for the determination of partition coefficients (log D) from low drug amounts
Several procedures based on the shake-flask method and designed to require a minimum
amount of drug for octanol–water partition coefficient determination have been established …
amount of drug for octanol–water partition coefficient determination have been established …
[HTML][HTML] Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain
…, H Knobel, MC Cánepa, SC Espinosa… - Clinical Microbiology …, 2020 - Elsevier
Objectives To analyse the characteristics and predictors of death in hospitalized patients
with coronavirus disease 2019 (COVID-19) in Spain. Methods A retrospective observational …
with coronavirus disease 2019 (COVID-19) in Spain. Methods A retrospective observational …
Dopamine receptors–IUPHAR R eview 13
JM Beaulieu, S Espinoza… - British journal of …, 2015 - Wiley Online Library
… The D 1 -class receptors (D 1 and D 5 receptors) are primarily coupled to Gα s/olf proteins
and stimulate the activity of AC and the production of the second messenger cAMP (Figure 1). …
and stimulate the activity of AC and the production of the second messenger cAMP (Figure 1). …
DEAH-box RNA helicases in pre-mRNA splicing
F De Bortoli, S Espinosa, R Zhao - Trends in biochemical sciences, 2021 - cell.com
In eukaryotic cells, pre-mRNA splicing is catalyzed by the spliceosome, a highly dynamic
molecular machinery that undergoes dramatic conformational and compositional …
molecular machinery that undergoes dramatic conformational and compositional …
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle …
K Bouzakri, M Roques, P Gual, S Espinosa… - Diabetes, 2003 - Am Diabetes Assoc
… trypsin digestion and were grown in Ham’s F10 medium supplemented with 20% FCS and
… differentiate into myotubes in Dulbecco’s modified Eagle’s medium containing 2% FCS and …
… differentiate into myotubes in Dulbecco’s modified Eagle’s medium containing 2% FCS and …
[PDF][PDF] A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
… Other association studies, whether genome-wide or candidate gene based, have not matched
Allison’s discovery, in terms of effect size or proportion of the variance explained. However…
Allison’s discovery, in terms of effect size or proportion of the variance explained. However…
Genetic diversity among sapoviruses
…, WM Zhong, Y Jing, PW Huang, SM Espinosa… - Archives of …, 2004 - Springer
… To synthesize long cDNAs in the capsid region, SuperScriptTM II RNA polymerase was
used according to the manufacturer’s protocol (Life Technologies, Inc. Gaithersburg, MD). The …
used according to the manufacturer’s protocol (Life Technologies, Inc. Gaithersburg, MD). The …
A pulsating auroral X-ray hot spot on Jupiter
Jupiter's X-ray aurora has been thought to be excited by energetic sulphur and oxygen ions
precipitating from the inner magnetosphere into the planet's polar regions 1 , 2 , 3 . Here we …
precipitating from the inner magnetosphere into the planet's polar regions 1 , 2 , 3 . Here we …
An empirical evaluation of camera trap study design: How many, how long and when?
…, MV Cove, P Ding, S Espinosa… - Methods in Ecology …, 2020 - Wiley Online Library
Camera traps deployed in grids or stratified random designs are a well‐established survey
tool for wildlife but there has been little evaluation of study design parameters. 2.We used an …
tool for wildlife but there has been little evaluation of study design parameters. 2.We used an …
Epidemiological and clinical features of hMPV, RSV and RVs infections in young children
C Manoha, S Espinosa, SL Aho, F Huet… - Journal of clinical …, 2007 - Elsevier
BACKGROUND: Human metapneumovirus (hMPV) has recently been isolated from children
with acute respiratory tract infections (RTIs). The epidemiological and clinical characteristics …
with acute respiratory tract infections (RTIs). The epidemiological and clinical characteristics …