Peri-conception parental obesity, reproductive health, and transgenerational impacts
Maternal over-nutrition during pregnancy is a risk factor for pregnancy complications and is
increasingly associated with adverse childhood outcomes such as increased propensity for …
increasingly associated with adverse childhood outcomes such as increased propensity for …
Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring
Background: The global rates of male overweight/obesity are rising, approaching 70% of the
total adult population in Western nations. Overweight/obesity increases the risk of chronic …
total adult population in Western nations. Overweight/obesity increases the risk of chronic …
[HTML][HTML] Oxidative stress and reproductive function: reactive oxygen species in the mammalian pre-implantation embryo
In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …
are necessary for normal embryo formation. However, at pathological levels, they result in …
[HTML][HTML] Application of laser in seam welding of dissimilar steel to aluminium joints for thick structural components
Laser welding-brazing technique, using a continuous wave (CW) fibre laser with 8000 W of
maximum power, was applied in conduction mode to join 2 mm thick steel (XF350) to 6 mm …
maximum power, was applied in conduction mode to join 2 mm thick steel (XF350) to 6 mm …
Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring
NO McPherson, JA Owens… - American Journal of …, 2015 - journals.physiology.org
… Postmortem and metabolite data represent 7 females from 7 litters representing n = 6 HE
and n = 5 CC males and 8 females from 8 litters representing n = 7 HC and n = 6 HH and HCE …
and n = 5 CC males and 8 females from 8 litters representing n = 7 HC and n = 6 HH and HCE …
[PDF][PDF] Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
…, JA Mathers, L Becker, F Carneiro, N MacPherson… - Cancer cell, 2002 - cell.com
We report that human secretory breast carcinoma (SBC), a rare subtype of infiltrating ductal
carcinoma, expresses the ETV6-NTRK3 gene fusion previously cloned in pediatric …
carcinoma, expresses the ETV6-NTRK3 gene fusion previously cloned in pediatric …
Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British Columbia
…, C Fitzgerald, K Gill, R Klasa, N MacPherson… - Journal of clinical …, 2005 - ascopubs.org
Purpose For more than two decades, cyclophosphamide, doxorubicin, vincristine, and
prednisone (CHOP) has been the standard therapy for diffuse large B-cell lymphoma (DLBCL). …
prednisone (CHOP) has been the standard therapy for diffuse large B-cell lymphoma (DLBCL). …
[HTML][HTML] Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring
Paternal health cues are able to program the health of the next generation however the
mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased in …
mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased in …
Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an “obesogenic” diet
… n = 8 between treatment groups by either sacrifice for litters n … mice (F0 n = 9 represented
per F1 diet; ie, n = 4 CD F0, n = 5 … to either the same CD (n = 34 males) or HFD (n = 33 males; 1 …
per F1 diet; ie, n = 4 CD F0, n = 5 … to either the same CD (n = 34 males) or HFD (n = 33 males; 1 …
[HTML][HTML] Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer
NR West, K Milne, PT Truong, N Macpherson… - Breast cancer …, 2011 - Springer
… We also examined the association between TIL and long-term chemotherapeutic efficacy
in a second cohort of ER-negative tumors (n = 255) with longer than 6 years of median follow-…
in a second cohort of ER-negative tumors (n = 255) with longer than 6 years of median follow-…