Mechanisms of cancer cachexia

MJ Tisdale - Physiological reviews, 2009 - journals.physiology.org
Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal
muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened …

Cachexia in cancer patients

MJ Tisdale - Nature Reviews Cancer, 2002 - nature.com
Cachexia — the massive (up to 80%) loss of both adipose tissue and skeletal muscle mass
— is a significant factor in the poor performance status and high mortality rate of cancer …

Biology of cachexia

MJ Tisdale - Journal of the National Cancer Institute, 1997 - academic.oup.com
About half of all cancer patients show a syndrome of cachexia, characterized by loss of
adipose tissue and skeletal muscle mass. Such patients have a decreased survival time, …

Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial

…, MD Barber, NK Aaronson, AC Voss, MJ Tisdale - gut, 2003 - gut.bmj.com
Aim: N-3 fatty acids, especially eicosapentaenoic acid (EPA), may possess anticachectic
properties. This trial compared a protein and energy dense supplement enriched with n-3 fatty …

The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer

MD Barber, JA Ross, AC Voss, MJ Tisdale… - British journal of …, 1999 - nature.com
Previous studies have suggested that administration of oral eicosapentaenoic acid (EPA) will
stabilize weight in patients with advanced pancreatic cancer. The aim of the present study …

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

M Tisdale, SD Kemp, NR Parry… - Proceedings of the …, 1993 - National Acad Sciences
Resistant variants of human immunodeficiency virus type 1 (HIV-1) have been selected by
limited passage in MT4 cells of both wild-type and 3'-azido-3'-deoxythymidine (AZT, …

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

…, MH St Clair, LR Boone, M Tisdale… - Antimicrobial agents …, 1997 - Am Soc Microbiol
1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol,
is a carbocyclic nucleoside with a unique biological profile giving potent, selective …

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement

…, L Zhang, D Gor, BW Snowden, M Tisdale - Journal of clinical …, 2004 - Elsevier
Background: The antiviral effect of anti-influenza drugs such as zanamivir may be demonstrated
in patients as an increased rate of decline in viral load over a time course of treatment …

Characterization of a cancer cachectic factor

…, P Cariuk, T McDevitt, B Coles, K Fearon, M Tisdale - Nature, 1996 - nature.com
… degycosylation kit; lane 4, treatment with 2 M NaBH, in 0.1 M NaOH at 37 C for 16 h; lane 5,
… A mocktreated control showed no change in M. METHODS. Hybridomas were produced by …

Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss

…, KCH Fearon, CHC Dejong, MJ Tisdale - The international journal …, 2005 - Elsevier
Atrophy of skeletal muscle is common in patients with cancer and results in increased morbidity
and mortality. In order to design effective therapy the mechanism by which this occurs …