Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination of …

… No CS I patient has ever fathered or borne a child, although one patient reported to have
CS had a successful pregnancy [561 (this patient also had normal intelligence and other …

… Recent studies have shown that a minority of adults at risk for HD choose to undergo
presymptomatic genetic testing [Nance, 1999b]; this reinforces the thought that minors should not …

Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined
clinical markers to understand the early progression of Huntington’s disease (HD), prior to …

Mitochondrial (mt) impairment, particularly within complex I of the electron transport system,
has been implicated in the pathogenesis of Parkinson disease (PD). More than half of …

Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …

ContextOccasionally, 2 or more major neurodegenerative diseases arise simultaneously.
An understanding of the genetic bases of combined disorders, such as amyotrophic lateral …

… EPVegter-Van der Vlis M Oculomotor defects in patients with Huntington's disease and their
… EPVegter-Van der Vlis M Oculomotor defects in patients with Huntington's disease and their …

Objective: To assess the cognitive phenotype of glucocerebrosidase (GBA) mutation carriers
with early-onset Parkinson disease (PD). Methods: We administered a neuropsychological …

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases,
a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) …