Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology
of the microcirculation. Since its recent incorporation in the 2013 American College of …

Pulmonary involvement is one of the extra-articular manifestations of rheumatoidarthritis (RA)
and includes pleurisy, parenchymal nodules, interstitial involvement, and airway disease. …

… In this context, aerosol infection of mice lacking M cells have significantly delayed dissemination
to … While membrane damage induced by the ESX-1 secretion system of M. marinum are …

Background Preclinical studies suggest that Reed–Sternberg cells exploit the programmed
death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, …

Mycobacterium tuberculosis is an intracellular pathogen persisting within phagosomes
through interference with phagolysosome biogenesis. Here we show that stimulation of …

Some breast cancers have been shown to contain a small fraction of cells characterized by
CD44 + /CD24 −/low cell-surface antigen profile that have high tumor-initiating potential. In …

… A first set comprised 529 isolates from cosmopolitan origins representing the main M.
tuberculosis genetic lineages (n = 417) and other members of the M. tuberculosis complex (see …

Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide.
Studies have reported human pathogens to have geographically structured population genetics…

Purpose Cancer cells can exploit the programmed death-1 (PD-1) immune checkpoint pathway
to avoid immune surveillance by modulating T-lymphocyte activity. In part, this may occur …

In November 2004, a regional climate change workshop was held in Guatemala with the
goal of analyzing how climate extremes had changed in the region. Scientists from Central …