Cancer-specific T cells are required for effective anti-cancer immunity and have a central role
in cancer immunotherapy. However, emerging evidence suggests that only a small fraction …

Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the
clinical care of patients with cancer 1 . However, whether the T cell response to checkpoint …

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving
past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-…

… This score system has become the gold standard for risk assessment in patients with de
novo MDS, and is widely used for stratification in clinical trials as well as for patient-selection in …

… That mRNA can distribute into both neuronal axons and dendrites is well established.
However, the mechanism by which specific mRNAs are transported is still largely a mystery. What …

… the development of synchronous metastatic disease as well as local progression. Compared
to … Wells should have been listed as Daniel K. Wells. The errors have been corrected in the …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

… were chronically stimulated for 8 d were highly enriched for genes upregulated in tumor-infiltrating
exhausted T cells from both mouse models and patients as well as T cells isolated …

The design of a code which uses different stepsizes for different components of a system of
ordinary differential equations is discussed. Methods are suggested which achieve moderate …