Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
… (C) These data were generated as described in panel B except that the indicator plasmids
… in B, using the pCMV-luc-miR-30(P) indicator plasmid, and are presented as shown in B. …
… in B, using the pCMV-luc-miR-30(P) indicator plasmid, and are presented as shown in B. …
[PDF][PDF] Transcription and processing of human microRNA precursors
BR Cullen - Molecular cell, 2004 - cell.com
MicroRNAs have recently emerged as key posttranscriptional regulators of eukaryotic gene
expression, yet our understanding of how microRNA expression is itself controlled has …
expression, yet our understanding of how microRNA expression is itself controlled has …
A review of screening tests for cognitive impairment
The merit of screening for dementia and cognitive impairment has been the subject of recent
debate. One of the main limitations in this regard is the lack of robust evidence to support …
debate. One of the main limitations in this regard is the lack of robust evidence to support …
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
X Cai, CH Hagedorn, BR Cullen - Rna, 2004 - rnajournal.cshlp.org
The factors regulating the expression of microRNAs (miRNAs), a ubiquitous family of ~22-nt
noncoding regulatory RNAs, remain undefined. However, it is known that miRNAs are first …
noncoding regulatory RNAs, remain undefined. However, it is known that miRNAs are first …
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
MH Malim, J Hauber, SY Le, JV Maizel, BR Cullen - Nature, 1989 - nature.com
HUMAN immunodeficiency virus type 1 (HIV-1) replication requires the expression of two
classes of viral mRNA. The early class of HIV-1 transcripts is fully spliced and encodes viral …
classes of viral mRNA. The early class of HIV-1 transcripts is fully spliced and encodes viral …
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
… Target sequences were either P complementary or were designed to form a central B. A
random sequence, for which no complementary small RNA is known to exist, was used as a …
random sequence, for which no complementary small RNA is known to exist, was used as a …
[PDF][PDF] Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
Animal cells have recently been shown to express a range of ∼22 nucleotide noncoding
RNAs termed micro RNAs (miRNAs). Here, we show that the human mir-30 miRNA can be …
RNAs termed micro RNAs (miRNAs). Here, we show that the human mir-30 miRNA can be …
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …
Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells
J Berger, J Hauber, R Hauber, R Geiger, BR Cullen - Gene, 1988 - Elsevier
… 10 1 (Panel A) or 100 1 (Panel B) of media from transfected cultures. The assay was performed
… Cullen, BR: Use of eukaryotic expression technology in the functional analysis of cloned …
… Cullen, BR: Use of eukaryotic expression technology in the functional analysis of cloned …
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs
… b, HSV-1 genomic sequence showing the antisense orientation and overlap of mature
miR-H6, and the predicted sequence of miR-H1 (ref. 15). c, qRT–PCR analysis verifying the …
miR-H6, and the predicted sequence of miR-H1 (ref. 15). c, qRT–PCR analysis verifying the …