There is increasing interest in developing a reliable, affordable and accessible disease
biomarker of Parkinson's disease (PD) to facilitate disease modifying PD-trials. Imaging …

Response criteria for paediatric high-grade glioma vary historically and across different
cooperative groups. The Response Assessment in Neuro-Oncology working group developed …

Background Clinical imaging data are typically stored and transferred in the DICOM format,
whereas the NIfTI format has been widely adopted by scientists in the neuroimaging …

Background— Thromboembolic disease secondary to complicated carotid atherosclerotic
plaque is a major cause of cerebral ischemia. Clinical management relies on the detection of …

Disconnection of cognitively important processing regions by injury to the interconnecting
white matter provides a potential mechanism for cognitive dysfunction in multiple sclerosis. …

Background: Current magnetic resonance techniques generate high signal from venous
blood and show thrombi as filling defects. Magnetic resonance direct thrombus imaging (MRDTI…

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease (PD).
An ideal imaging marker would directly mirror the loss of substantia nigra dopaminergic …

BACKGROUND: Carotid endarterectomy is beneficial in severe (>70%) symptomatic carotid
stenosis. The risk of stroke in moderate carotid stenosis (50%-69%) is modest, and so the …

The locus coeruleus (LC) is a brainstem structure that has widespread cortical and sub-cortical
projections to modulate states of attention. Our understanding of the LC's role in both …

Removal of the anterior temporal lobe (ATL) is an effective surgical treatment for intractable
temporal lobe epilepsy but carries a risk of language and verbal memory deficits. …