Adiponectin is a recently described adipokine that has been recognized as a key regulator
of insulin sensitivity and tissue inflammation. It is produced by adipose tissue (white and …

The presence of a diabetic cardiomyopathy, independent of hypertension and coronary artery
disease, is still controversial. This systematic review seeks to evaluate the evidence for the …

Background Antimicrobial stewardship is advocated to improve the quality of antimicrobial
use. We did a systematic review and meta-analysis to assess whether antimicrobial …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene
encoding leptin 1 , an adipocyte-specific secreted protein which has profound effects on appetite …

Background The level of evidence for HIV transmission risk through condomless sex in
serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral …

Importance A key factor in assessing the effectiveness and cost-effectiveness of antiretroviral
therapy (ART) as a prevention strategy is the absolute risk of HIV transmission through …

The accurate mapping of reads that span splice junctions is a critical component of all
analytic techniques that work with RNA-seq data. We introduce a second generation splice …

Background Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose
metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In …

Frequent subgraph mining is an active research topic in the data mining community. A
graph is a general model to represent data and has been used in many domains like …