The methods for treating experimental data in the isomorphous replacement and anomalous
scattering methods of macromolecular phase determination have undergone considerable …

BUSTER-TNT is a maximum-likelihood macromolecular refinement package. BUSTER
assembles the structural model, scales observed and calculated structure-factor amplitudes and …

The BCL-2 inhibitor venetoclax combined with hypomethylating agents or low-dose
cytarabine represents an important new therapy for older or unfit patients with acute myeloid …

A typical diffraction experiment will generate many images and data sets from different crystals
in a very short time. This creates a challenge for the high-throughput operation of modern …

… For example, for threefold NCS chain A would have LSSR to chain B together with LSSR
for chain A to chain C in addition to a separate set of LSSR coupling chain B and chain C. It …

Why CLL recurs in patients who achieve remission with the BCL2 inhibitor venetoclax has
been unknown. We provide the first description of an acquired point mutation in BCL2 arising …

Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative
treatment for patients with various leukemias. TP-53 controls apoptosis upstream of where BCL-…

… C The number of nanopore reads generated from each sample, and the percentage of
reads that were assigned a cell barcode. D Distribution of UMI counts per cell for Illumina and …

… (C) Subclonal phylogeny for TN1 showing private and public subclones. Private subclones
in dark blue. Mutations arising from signature 17 represented in pink along branches. …

… the relation k⊥ = c/r, for any constant c. (Any result for a cross section would get the
same number of extra factors of c in the numerator as in the denominator.) We make the …